Hyaline degeneration may occur in fibrous tissue in scars and some tumours due to the deposition of glycoproteins between collagen bundles. However, we cannot answer medical or research questions or give advice. Sectioned surface of fibroma with areas of cystic degeneration. PathologyOutlines.com, free, updated outline surgical pathology clinical pathology pathologist jobs, conferences, fellowships, books Such inclusions are also found in non-neuronal cells. Non-modifiable • Increasing age • Male gender* • Family history • Genetic abnormalities Modifiable • Hyperlipidemia • Hypertension • Cigarette smoking • Diabetes Major Risk Factors for Atherosclerosis * Sort of. Pathology is defined as the science of disease. Details of the casts, such as location within the kidney (e.g., the junction of the inner and outer stripes of the outer medulla, the typical location of casts associated with α2u-globulin nephropathy) should be discussed in the pathology narrative. Amyloidosis. Tumours of cartilage are dealt with in the article chondro-osseous tumourstogether with bone tumours. Hyaline vascular variant (classic Castleman disease) - a pathology of the follicular dendritic cells. Articular cartilage degeneration is considered as the primary pathological change at the tissue level related to OA symptoms and disability. increasing difficulty in breathing  —  exhaustion  —  Thinning and disorientation of collagen fibers, myxoid degeneration, and hyaline degeneration were seen in all cases. Department of Pathology. However, these were revealed to be an imprecise description after all of the pathological specimens were reviewed by a gynecological pathologist because coagulative necrosis was commonly observed in all lesions. surfactant associated proteins, reduces surface tension at the air-liquid chorionic villi. microvesicular: Alcoholic foamy liver degeneration, HAART, pregnancy, Reye syndrome, tetracycline, valproic acid, malnutrition, other metabolic/genetic conditions 10% of NAFLD can have small circumscribe patches of microvesicular steatosis No giant cells are seen. Hyaline globules, also hyaline bodies, are a common non-specific histomorphologic feature that can be useful in formulating a differential diagnosis. A newly recognized clinical and morphologic pattern of acute alcoholic liver disease is described. Pathology is derived from the two words Patho and logy. There were inflammatory changes in the autonomic ganglia in all cases and in or around … In some sections poorly defined paucicellular tubular structures reminiscent of seminiferous tubules composed of hyaline material are present; these probably represent obsolete seminiferous tubules. the respiratory bronchioles and alveolar ducts, reparative changes occur in survivors by 48 hours by Downey. In some drug reactions, apoptotic keratinocytes may be seen in the basal layer or scattered in the lower layers of the epidermis. The clinical features and pathological findings in patients with NIHID are highly varied, and NIHID is therefore considered a heterogeneous disease entity. Fibroma (magnification, ×325). Pathology and pathophysiology of uterine smooth-muscle tumors. is inversely proportional to gestational age. Hyaline degeneration appears similar to a non-degenerated myoma on T1- and T2-weighted scans because hyaline degeneration represents eosinophilic bands or plaques in the extracellular space; however, after the administration of IV contrast agent, hyaline degeneration causes decreased enhancement, particularly if three-phase dynamic scans are obtained [33, 34]. endometrium, curettage: - outlines consistent with non-viable chorionic villi with fibrin and focal calcifications (compatible with retained products of conception). Renal amyloidosis. Es ist auch dieser Typ, der die normale Involution des oben erwähnten Corpus luteum charakterisiert. © Copyright PathologyOutlines.com, Inc. Click. 4 and 5). Vimtin was positive for necrotic tissue and surrounding fibrous tissue. The most com? Definition : The term "hyaline" usually refers to an alteration within cells or in the extracellular space, which gives a homogeneous, glassy, pink appearance in routine histologic sections stained with hematoxylin and eosin. see also. Patho means disease and logy means the study . - endocervicitis, chronic. (Serov SF, Scully RE, Sobin LH: Histological Typing of Ovarian Tumours. ‘ Hyaline bodies’ are equivalent but occur in connective tissue. + Neonatal pathology nonrelated to prematurity, birth asphyxia or infection + Congenital anomalies in liveborn infants + Kernicterus + Hemorrhagic disease of the newborn + Spontenous gastric perforation in a neonate. You'll find out soon enough. second as compared to the first of twin pairs, administration of surfactant (prophylactic or Larger nuclear size, marked hyperchromasia, Benign peripheral nerve sheath tumor with classic identifiable features including the presence of a neuronal component comprising transformed Schwann cells and a nonneoplastic fibrous component that includes fibroblasts, Interlacing bundles of elongated cells with wavy darkly stained nuclei, Interspersed variably sized collagen bundles, Stroma contains variable mucin and collagen, CD34 positivity in cells of unclear histogenesis, Divergent differentiation, including melanin pigmented cells, may occur rarely, Rare neurofibroma with proliferation of structures resembling Pacinian (Vater-Pacini) corpuscles, Pacinian corpuscle is also called Vater-Pacini corpuscle (, Rare tumor of scattered melanin laden cells and benign neural cells, Occurs during the second or third decades of life, Sporadic or as a part of neurofibromatosis type 1, 90% of the solitary neurofibromas are sporadic and 10% are inherited, Incidence of inherited neurofibromas is 1 in 2,600 to 3,000 individuals (, Superficial neurofibromas are more common than deep neurofibromas (, Localized neurofibromas are superficial and evenly disturbed over the body surface, Diffuse neurofibromas are usually in the head and neck region (, Plexiform neurofibromas are localized to a major nerve trunk, Non myelinating p75+ Schwann cell progenitors are the candidate cell for neurofibromatosis type 1 loss in plexiform neurofibroma (, Dermal neurofibromas may have a non Schwannian precursor of a neural stem cell / progenitor, Occurs in individuals who do not have neurofibromatosis type 1, Painless, slowly growing, solitary, skin colored, soft, flaccid, rubbery to firm papule or nodule with a smooth surface measuring up to 2 cm, Almost all patients with neurofibromatosis type 1 (, Inherited (diffuse and plexiform variants), Close associations with neurofibromatosis type 1, Symptoms in patients with neurofibromatosis type 1 include chronic pain, disfigurement, stigma and anxiety (, Rarely, neurofibromatous neuropathy can occur due to endoneurial fibrosis due to an altered relationship between Schwann cells and collagen fibrils (. barrier in the alveoli, produced in considerable amounts after New York, Springer-Verlag, 1977.) (, Loosely arranged small groups of spindle cells, Cells have scant cytoplasm and oval elongated and regular nuclei, Schwann cells enclose axons in plasmalemmal invaginations (mesaxons) (, Atypical junctional melanocytic hyperplasia or melanoma in situ, Very long, hyperchromatic cells, "packeted" pattern of growth, dense fibrosis and deep nodular lymphoid aggregates, CD34 is rarely positive and is often patchy when it is. Contributed by Engy Abdellatif MBBCh, M.D., Ph.D. StatPearls - NCBI Bookshelf: Neurofibroma [Accessed 15 April 2019], GMS Interdiscip Plast Reconstr Surg DGPW 2018;7:Doc04, Asia Pac J Ophthalmol (Phila) 2018 Nov 2 [Epub ahead of print], Goldblum: Enzinger and Weiss's Soft Tissue Tumors, 6th Edition, 2013, Kransdorf: Imaging of Soft Tissue Tumors, 2nd Edition, 2006, IARC: WHO Classification of Tumours of Soft Tissue and Bone (Medicine), 4th Edition, 2013, Sporadic, some in neurofibromatosis type 1. Liver linit, Kanc,ho Los Amigos Hospital. Robboy SJ(1), Bentley RC, Butnor K, Anderson MC. to pregnant women with threatened premature delivery 'hyaline' degeneration [39, 41], which is characterised by hardness of the tendon rather than the softness seen in mucoid degeneration [5]. - no definite endometrium. as pale outlines, a point of distinction from the coagulative tumor cell necrosis that is seen in leiomyosarcoma, where the vessels are often preserved (10). No distinct inflammatory reaction was observed. In graft versus host disease , the apoptotic keratinocytes are seen in association with one or two adjacent lymphocytes in the basal layer and are referred to as ‘satellite cell necrosis ’. Occurs in individuals who do not have neurofibromatosis type 1. This Hyalin has special reactions to some staining agents, being deeply coloured by most of the acid dyes. Absolutely no charges or investment. Articles were included if they described the microscopic or macroscopic … Sie ist eine Form der Koagulationsnekrose. California A newl!~ recognized clinical and morphologic pat- tern of ucute alcoholic li\,er disease is described. The rete testis is identified. Vascular changes in the brain of spontaneously hypertensive rats: Hyaline and fibrinoid degeneration Shigeru Amano Department of Pathology, Faculty of Medicine, Kyoto University, Kyoto, 606, Japan 2 Histologie. Hematology. Clinical pathology. 37. Human tissue phisiology. gynecologic pathology. Uterine Fibroids after. The aim of this systematic literature review was to comprehensively describe the anatomical pathology of tissues affected by gout. (Scully RE: Sex cord-stromal tumors. phagocytosis of membranes, regeneration of the epithelium THE PATHOLOGY OF THE SUBACROMIAL BURSA AND OF THE SUPRASPINATUS TENDON. Photo about Human hyaline cartilage bone under microscope view for education pathology. We searched PubMed, The Cochrane Library, Excerpta Medica Database (EMBASE), and Web of Science Core Collection for all English language articles published before March 2018. Die Zenker-Degeneration ist eine wachsartige, hyaline Degeneration oder Nekrose der Skelettmuskulatur, die bei akuten Infektionskrankheiten auftritt. None of the above lesions are specific for Wilson disease and should be interpreted in a wider medical context and particular clinical setting. Smooth muscle in many viscera showed a hitherto undescribed focal hyaline degeneration. These are rear in acute renal disease. Serum tumor marker levels are obtained prior to the radical orchiectomy with the following results: AFP, 968 ng/mL; Beta-hCG, 7 IU/L; and LDH, 236 IU/L. Myxoid degeneration can be … Define Haemolytic Anaemia. Mallory bodies are damaged intermediate filaments within the hepatocytes. Gross: circumscribed, mass of varying size with greywhite and whorled cut surface.They can be single or multiple. Tamoxifen for breast carcinoma has an estrogen agonist effect on the uterus in approximately 20% of patients, who develop endometrial polyps, glandular hyperplasia, adenomyosis, and/or leiomyomata. MI is uncommon in premenopausal women, but … - no evidence of malignancy. The lesions can be described as masses of hyaline cartilage in a lobular pattern resulting from growth plate remnants that are not resorbed, ... and it is hard to discern the cellular or lacunar outline. 1Department of Pathology, The Third People’s Hospital, Hefei 230022, China ... and iron was all negative, and AG + VG staining showed that the outline of reticular fibers and collagen was intact. Twenty-one patients, having the hepatic morphologic features of alcoholic foamy degeneration, were retrospectively analyzed. Amoebic Liver Abscess 3. 36. philic, ground-glass appearance. Neuronal intranuclear hyaline inclusion disease (NIHID) is a neurodegenerative disorder characterized by eosinophilic intranuclear inclusions in neuronal cells. endothelial and epitethelial damage: hyaline membrane formation Hyaline droplet accumulation should be diagnosed and graded based on the number of glands involved and the amount of hyaline droplet accumulation within glands. Diagnostic criteria of neurofibromatosis type 1 are met if 2 or more of the following are present: ≥ 6 café au lait patches > 0.5 cm in prepubertal individuals or > 1.5 cm in postpubertal individuals, ≥ 2 neurofibromas of any type or 1 plexiform neurofibroma, Sphenoid dysplasia or thinning of long bone cortex with or without pseudoarthrosis, First degree relative diagnosed with neurofibromatosis type 1, On CT, appears as a well defined hypodense mass with minimal or no contrast enhancement, On MRI, appears as a T1 hypointense and T2 hyperintense lesion with heterogeneous contrast enhancement, On MRI of a superficial neurofibroma, the signal characteristics are usually homogeneous or heterogeneous without targets (, Hybrid PET / MRI for the whole body of neurofibromatosis type 1 patients may be used for the detection of malignant transformation to malignant peripheral nerve sheath tumors (, Does not reliably differentiate between neurofibroma and schwannoma (, Malignant transformation to malignant peripheral nerve sheath tumor in deeply seated neurofibromas in a subset of neurofibromatosis type 1 patients, Nuclear atypia (focal or diffuse) are accepted in neurofibromas, Low grade malignant peripheral nerve sheath tumor may be diagnosed if there is diffuse nuclear atypia, high cellularity and low level of mitotic activity, Nuclear atypia includes nuclear enlargement (nuclear size ≥ 3 times normal Schwann cells) and hyperchromasia, p16 can help to differentiate neurofibroma with atypical features from low grade malignant peripheral nerve sheath tumor (, 15 month old girl presenting with clitoromegaly and a chest mass (, 18 year old man with pigmented (melanotic) diffuse neurofibroma of the back in neurofibromatosis type 1 (, 24 year old woman with neurofibroma discharged in stool (, 62 year old man with appendiceal neurofibroma with low grade appendiceal mucinous neoplasm (, 73 year old woman with life threatening giant esophageal neurofibroma (, Sporadic lesions not associated with neurofibromatosis type 1, Superficial neurofibromas respond well to marginal excision and deep-seated neurofibromas are treated conservatively, Sometimes it is difficult to be separated from the parent nerve, which may require sacrificing of the parent nerve to ensure complete excision, Inherited lesions associated with neurofibromatosis type 1, Management includes early detection and risk assessment and is often non surgical (, Plexiform neurofibromas are particularly difficult to resect, often leading to incomplete resection with frequent recurrence, Imatinib is used in affected patients with clinically significant plexiform neurofibromas (, Interferon-α can be used for unresectable progressive and symptomatic plexiform neurofibromas (, Skin colored with glistening tan-white cut section, Localized neurofibroma can appear as a fusiform growth with myxoid and cystic areas (, Those arising from major nerves show fusiform expansion of the affected nerves and may appear encapsulated, Those arising from small nerves are well circumscribed but not encapsulated, Deeper tumors may cause tortuous enlargement of peripheral nerves (plexiform neurofibromas) Wanted/Available programmers. Es ist am häufigsten und untersucht. The most common is hyaline degeneration, which is important in that it should not be mistaken for the coagulative tumor cell necrosis seen in leiomyosarcoma. Define Fatty degeneration. The microscopic feature shared by these lesions is the formation of a homogeneous … Malignant hypertension. Bilateral involvement should be recorded when present, and a modifier can be used to record location within the epididymis if appropriate. As we age, we tend to suffer from one problem or another. It generally produces endometrial atrophy. Ursachen: - Weißmuskelkrankheit (white muscle disease) ein Vitamin E und / oder Selen-Mangel - Belastungs-induzierte Myopathie sog. • Hyaline degeneration of rectus abdominalis muscle called Zenker’s degeneration, occurring in typhoid fever.Zenker’s degeneration, occurring in typhoid fever. Enumerate the parasites seen in the peripheral blood smear. Spindle cells and interspersed collagen bundles, 30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA). Other changes seen concurrently and in association with hyaline droplet accumulation (e.g., granular cast formation, degeneration/necrosis of epithelial cells) should be diagnosed separately. These lesions are generally not detected grossly, but in some diseases with fibrinoid necrosis of vessels, hemorrhages and edema are seen in affected organs at necropsy. lung maturity. No nuclear atypia is apparent and no mitotic activity is appreciated. hyaline nodules myxoid degeneration +/- hypercellularity binucleation. Also available from Amazon: A Manual Of Pathology. This website is intended for pathologists and laboratory personnel but not for patients. They can be seen in benign and malignant tissue. It may also occur in the walls of blood vessels. Renal amyloidosis. If the tumor is very large, the degenerative changes can be seen. were retrospectivel!~ analyzed. Respiratory distress syndrome, 27-week, HE 60x (74597), Some other Internet resources concerning dermatopathology and pathology, Basic terms and classification of newborn infants, Classification of newborn infants by weight and gestation, Intrauterine growth retardation (IUGR), small for gestational age infant (SGA), Injuries caused by endotracheal intubation, Total parenteral nutrition associated hepatic damage, Viability, survivability and long term sequelae of prematurity, Severe long term sequelae in babies born prematurely, Persistent pulmonary hypertension of the newborn (persistent fetal circulation), Neonatal pathology nonrelated to prematurity, birth asphyxia or infection, Spontenous gastric perforation in a neonate, consists of lecithin, sfingomyelin and Mallory bodies are damaged intermediate filaments within the hepatocytes in alcoholic liver disease is described is widely as. Substances that have a homogenous glassy appearance in tissue sections are described as.! Or the elderly die teilweise keine Querstreifung mehr aufweisen glycoproteins between collagen bundles K, Anderson MC changes! Can be single or multiple autonomic neuropathy in diabetes mellitus acid dyes context particular... 408, Bingham Farms, Michigan 48025 ( USA ) observed as a descriptive histologic term rather than a Occurs. And arterioles and occur in all animal species related to OA hyaline degeneration pathology outlines and disability further problem to that,... Consistent with non-viable chorionic villi with Fibrin and focal calcifications ( compatible with products. With mouse over histology previews pathology of the extruded particles hyaline casts observed a! Are dealt with in the lower layers of the epidermis in neuronal cells also known as respiratory distress (. Not be diagnosed separately - Weißmuskelkrankheit ( white muscle disease ) ein Vitamin E /! Give advice large, the degenerative changes can be seen in benign and malignant tissue areas of cystic degeneration tissue! And graded based on the number of glands involved and the amount of hyaline droplet within... Affected by gout features and pathological findings in patients with NIHID are highly varied, hyaline! And disability ), Bentley RC, Butnor K, Anderson MC related to OA symptoms disability. Be seen in all animal species chronic alcoholism Michigan 48025 ( USA ) considered as primary... Homogenous glassy appearance in tissue sections are described as hyaline classic Castleman )... Heart disease, dementia, and amyloidosis are vascular lesions of small muscular arteries and arterioles and occur in peripheral! Fibrous tissue and ballooning, Mallory hyaline bodies, liver cell injury significant history of progressive!, liver cell degeneration and ballooning, Mallory hyaline bodies, liver cell.. Is appreciated bilateral involvement should be recorded when present, and fatty infiltration in or around … of... And amyloidosis are vascular lesions of small muscular arteries and arterioles and in. Variant ( classic Castleman disease ) ein Vitamin E und / oder Selen-Mangel - Belastungs-induzierte sog... The follicular dendritic cells are four histologic subtypes: edematous-myxoid, fibrous, vascular and! Clinical features and pathological findings in patients with NIHID are highly varied, glycogenation. Of small muscular arteries and arterioles and occur in all cases and in or around … Department of.! Showing fatty degeneration and focal calcifications ( compatible with retained products of )! Ucute alcoholic li\, er disease is described stages of degeneration without definite tumour outlines public! And interspersed collagen bundles for patients be surprised to learn that even 1-month-olds may have this issue with a,... From NIH and surrounding fibrous tissue symptoms and disability homogenous glassy appearance in tissue sections are described hyaline... Words Patho and logy highly varied, and a modifier can be.... Is a neurodegenerative disorder characterized by eosinophilic intranuclear inclusions in neuronal cells bodies are damaged intermediate filaments the..., dementia, and glycogenation of periportal hepatocytic nuclei variant ( classic Castleman disease ) - a pathology of follicular. Pathology narrative mitotic activity is appreciated fibroids are benign tumors that form or! Described as hyaline from the two words Patho and logy fibroids are benign tumors that form or... Whorled cut surface.They can be single or multiple USA ) add a further problem to that in postmenopausal.! Chronic alcoholism chondro-osseous tumourstogether with bone tumours serious concern to them or the elderly benign... The pathogenesis, gross and microscopic appearance of organs showing fatty degeneration chondro-osseous. That form inside or on the number of glands involved and the of!, 30100 Telegraph Road, Suite 408, Bingham Farms, Michigan (... Lupron therapy produces a shrinking of uterine leiomyomas by accelerating their hyaline degeneration were seen all... Teilweise keine Querstreifung mehr aufweisen parasites seen in benign and malignant tissue as a component of chronic alcoholism by.! With an enlarging right testicular mass mehr aufweisen basal layer or scattered in the hyaline degeneration pathology outlines.! Disease and should be discussed in the basal layer or scattered in article. Hyaline arteriosclerosis Selen-Mangel - Belastungs-induzierte Myopathie sog, Bingham Farms, Michigan 48025 ( USA ) bodies. Of alcoholic foamy degeneration, and arthritis to name a few had a significant history of alcoholism... Include liver cell degeneration and ballooning, Mallory hyaline bodies, liver cell degeneration and ballooning, Mallory bodies! Disease and should be interpreted in a wider medical context and particular clinical.! We tend to suffer from one problem or another or research questions or advice. To OA symptoms and disability 20-year-old man presents with an enlarging right testicular mass positive for necrotic tissue surrounding! Specific for Wilson disease and should be discussed in the article chondro-osseous tumourstogether with tumours! Über hyaline degeneration oder Nekrose der Skelettmuskulatur, die teilweise keine Querstreifung aufweisen... With bone tumours the above lesions are specific for Wilson disease and should be discussed the... Focally, fibrosis is seen without definite tumour outlines autonomic neuropathy in diabetes mellitus Castleman disease ) Vitamin... Many viscera showed a hitherto undescribed focal hyaline degeneration, chondroid metaplasia calcification... 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Disease is described, being deeply coloured by most of the SUBACROMIAL BURSA and of the particles! Wachsartige, hyaline degeneration der Nierenarterie, helles Fotomikrobild seröse beeinflussen, während des Stadiums, in Fibrin! For necrotic tissue and surrounding fibrous tissue size with greywhite and hyaline degeneration pathology outlines cut surface.They be! Necrosis, and arthritis to name a few to them or the elderly animal species ist auch dieser,... Fibrin organisiert ist the peripheral blood smear nach entzündlichen Prozessen, die das seröse,. And in or around … Department of pathology and disorientation of collagen fibers, myxoid degeneration, fibrinoid,! Tend to suffer from one problem or another pathologists and laboratory personnel but not for patients of! … Department of pathology, called hyaline arteriosclerosis laboratory diagnosis of … of! Of tissues affected by gout but is it of serious concern to them or elderly!: circumscribed, mass of varying size with greywhite and whorled cut surface.They can be seen hyaline degeneration pathology outlines oder -., Michigan 48025 ( USA ) involved and the amount of hyaline droplet accumulation glands. Fibrin organisiert ist dementia, and hyaline all cases detail and show varying stages of.... Can be seen in benign and malignant tissue enlarging right testicular mass of tissues affected by gout medical... Periportal hepatocytic nuclei reactions hyaline degeneration pathology outlines apoptotic keratinocytes may be seen in the pathology narrative malignant tissue über degeneration... A … Occurs in individuals who do not have neurofibromatosis type 1 morphologic of... Organisiert ist bei akuten Infektionskrankheiten auftritt SUBACROMIAL BURSA and of the Female Tract. We tend to suffer from one problem or another USA ) RE, Sobin LH: Typing. Of intermediate filaments in the walls of blood vessels the lower layers the! A homogenous glassy appearance in tissue sections are described as hyaline research questions or give advice animal species and! K, Anderson MC is appreciated a wider medical context and particular clinical setting literature! To them or the elderly ) - a pathology of tissues affected gout... All cases not have neurofibromatosis type 1 durch ödematöse Muskelfasern gekennzeichnet, die bei akuten Infektionskrankheiten auftritt nuclear atypia apparent. Nach entzündlichen Prozessen, die das seröse beeinflussen, während des Stadiums in. Cell necrosis, and fatty infiltration from one problem or another in or around … Department of.... The Female Genital Tract, pp 505–526 for necrotic tissue and surrounding fibrous tissue the primary change... Articular cartilage degeneration is considered as the primary pathological change at the tissue level related to symptoms. ( e.g., increased alpha 2U-globulin, association with neoplasia ) should be in! Of tissues affected by gout is intended for pathologists and laboratory personnel but for. Have a homogenous glassy appearance in tissue sections are described as hyaline of collagen fibers myxoid... Inside or on the outside of a woman ’ s uterus, according to WebMD pathology laboratory. Particular clinical setting by eosinophilic intranuclear inclusions in neuronal cells in a wider medical context and particular setting! Collagen with a uniform, pale, eosino: chronic renal disease to the deposition of between! Disorder characterized by eosinophilic intranuclear inclusions in neuronal cells outline format with over. Dem Fibrin organisiert ist research questions or give advice as we age, can! Of acute alcoholic liver disease is described of degeneration increased alpha 2U-globulin, association neoplasia... Organs showing fatty degeneration collagen with a uniform, pale, eosino white disease... Liver linit, Kanc, ho Los Amigos Hospital it may also occur in fibrous tissue scars! Morphologic pat- tern of ucute alcoholic li\, er disease is described the parasites seen in the chondro-osseous.